In another report targeting MMP in the TME, a nanotheranostic system consisting of Au nanostar (AuNS) surface functionalized with bovine serum albumin (BSA), embedded with R-780 (I) iodides PS, and decorated with MMP2 polypeptides (Ac-GPLGIAGQ) (AuNS@BSA/I-MMP2) was designed for concurrent diagnosis and treatment of lung cancer cells. The gene discussed is MMP2; the disease is lung cancer.