Lactate formed in large amounts in tumor cells (Warburg effect) is cotransported with protons (H+) from tumor cells through monocarboxylate transporters (MCT1 and MCT4), which, on the one hand, leads to lactate accumulation (up to 45 mM) and, on the other, reduces the pH of the tumor microenvironment [7]. This evidence concerns the gene SLC16A1 and neoplasm.