SERGEF and allergic disease: Finally, two other genes were found associated with SHM in FB: E2F6, with a crucial role in cell cycle control that has been suggested to act as an inhibitory regulator of IL-3 and allergy [58]; and SERGEF, encoding a secretion-regulating guanine nucleotide exchange factor of unknown function and displaying a possible pathogenic variant removing an intronic branch-site sequence (C/A, CFA21:40329686, Canfam 3.1 assembly).