The results of these studies show association of brachycephaly with the RUNX2 gene on CFA12 [29], SMOC2 on CFA1 [30] and BMP3 on CFA32 [31], chondrodysplasia with FGF4 retrogene on CFA12 and CFA18 [32,33] and also with skull size [30]. This evidence concerns the gene SMOC2 and Brachycephaly.