Of these, four genes were determined to be related to bone development (PLXNA2 with prognathism, HHAT with the complex Nivelon-Nivelon-Mabille Syndrome, MBOAT2 with chondrocyte differentiation, and ITGAV with chondrodystrophy), and one to calcium homeostasis (HPCAL1). This evidence concerns the gene ITGAV and chondrodysplasia-pseudohermaphroditism syndrome.