Including a recombinant Microcin J25, a plasmid-encoded AMP isolated from a faecal strain of E. coli, at various doses (0.5, 1, or 2 mg/kg feed) in weaner feed, increased weight gain and feed intake, especially in the first two weeks post-weaning, but impaired the gain to feed ratio, reduced the diarrhoea index, reduced serum concentrations of the pro-inflammatory cytokines IL-6, IL-1β, and TNF-α, and increased the serum concentration of the anti-inflammatory IL-10 [223]. Here, IL1B is linked to Diarrhea.