Postmenopausal osteoporosis (PMOP) is a metabolic bone disease caused by imbalance between osteoblast bone formation and osteoclast bone resorption, and DGCR5 up-regulates Runx2 through miR-30d-5p to induce osteogenic differentiation, which contributes to ameliorate postmenopausal osteoporosis (PMOP), further affecting the growth of skeletal muscle [20]. The gene discussed is RUNX2; the disease is postmenopausal osteoporosis.