Consistently, we found that Jinqiao II tartary buckwheat at different dosages (5%, 10%, and 20%) lowered the increase in the HFD-induced serum lipid biochemical profiles, including serum TC, TG, and LDL-C levels; attenuated the abnormal liver function represented by AST and ALT levels; partially alleviated hepatic steatosis and fat accumulation; and suppressed the over-release of inflammatory cytokines, including TNF-α and IL-6, with the dosages of the intervention. Here, TNF is linked to fatty liver disease.