TRIM21 and disseminated candidiasis: Jianning reported that the pivotal role of Ssa1 in host cell invasion is reflected in the declined ability of Ssa1 null mutants to induce in vitro uptake by epithelial and endothelial cells themselves, and in mouse models of oropharyngeal candidiasis and disseminated candidiasis, where the virulence of the mutants was obviously diminished [78].