ACE and familial hypercholesterolemia: Additionally, enzymatically produced silkworm pupa hydrolysate is reported to possess several bioactive properties, such as inhibiting angiotensin-I converting enzyme (ACE) activity [70,71,72,73,74], antioxidant activity [78,79,80], immunomodulatory activity [81], improving hypercholesterolemia [75], and anti-tumor activity [76,77].