TP53 and neurodegenerative disease: Although protein aggregation and its role in disease pathogenesis has been confined mainly to neurodegenerative diseases, p53 aggregation has attracted interest in recent years, focusing on its involvement in cancer, given p53’s crucial role as a tumor suppressor and master regulator of many cellular processes, such as the cell cycle, apoptosis, DNA repair, inflammation, and metabolism (5,14,51).