Moreover, over activation of Notch1 signal drives metastasis in CRC in neutrophil-dependent manner via promoting chemokine CXCL5 (C-X-C Motif Chemokine Ligand 5) and transforming Growth Factor β (TGF-β) productions, triggering an inhibitory strategy to suppress T cell responses in the TME and create an immune-suppressed environment [17]. This evidence concerns the gene NOTCH1 and colorectal carcinoma.