Moreover, Leukemia-Associated Non-Coding IGF1R Activator RNA 1 (LUNAR1), a novel Notch-regulated lncRNA, was recently reported to be significantly upregulated in CRC tissues [188, 189], induced by Notch1 activation, enhancing CRC progression through sustaining insulin-like growth factor 1 receptor (IGF-1R) expression [188]. Here, NOTCH1 is linked to colorectal carcinoma.