Sonoshita et al., showed that inhibition of Notch-signal causes suppression in CRC tumor invasion and intravasation activated by knockdown of Amino-terminal enhancer of split (Aes) gene in ApcΔ716mice intestinal polyposis, pointing out to Notch-signal inhibition as a potential player during CRC metastasis prevention and treatment [222]. Here, TLE5 is linked to colorectal carcinoma.