Likewise, Fender et al., showed that higher level of the EMT-related proteins CD44, snail family transcriptional repressor 2 (SLUG), and SMAD family member 3(Smad-3), as well as phenotypic alterations in CRC cells, emerged from constitutive activation of NICD1 in CRC cells [22]. Here, SMAD3 is linked to colorectal carcinoma.