Silencing the Notch pathway enhances the cytotoxicity of tumor-infiltrating CD8+ T cells via increasing their production of pro-inflammatory cytokines such as interferon gamma (IFN-γ), interleukin-1β (IL-1β), IL-6, IL-8, tumor necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF) as well as reducing their PD-1 expression [182]. The gene discussed is IFNG; the disease is neoplasm.