NOTCH1 and colorectal carcinoma: Inhibition of FOXD2-AS1 expression in CRC cells resulted in an enhancement of E-cadherin protein expression, decreasing the expression of N-cadherin and the Snail protein as well as significant decrement in the Notch-related proteins (NICD and Hes-1) expression, suggesting that FOXD2-AS1 promoted CRC progression through regulation of EMT and Notch pathway [125].