In CRC, Notch1 overexpression is contributed to 5-FU resistance, Notch1 suppression via miR-139-5p overexpression increases 5-FU sensitization in CRC cells, depending on Notch1 downstream targets MRP-1 and BcL-2 downregulation [25]. The gene discussed is NOTCH1; the disease is colorectal carcinoma.