The Notch-related protein, Hes1, enhances CRC metastasis through induction of EMT; Upregulation of Hes1 contributed to loss of cell adhesion via repressing E-cadherin expression and enhancing N-cadherin, vimentin as well as the EMT inducer Twist-1 expressions [223]. The gene discussed is HES1; the disease is colorectal carcinoma.