It was reported that the levels of VEGF receptors were significantly higher in various pathological conditions, such as tumor development and vascular injury, indicating that VEGF has a promoting effect on the division and proliferation of endothelial cells; additionally, VEGF mediated by protein kinase C could induce endothelial cell proliferation, angiogenesis and repair through the activation of SPHK [42]. The gene discussed is VEGFA; the disease is neoplasm.