Meanwhile, it was found that SPHK1-S1P-S1PR1 signaling pathway activation enhances the homeostasis of endothelial barrier which is injured by endothelial inflammatory mediators, and activation of SPHK1 has a preventive effect on pulmonary edema induced by lipopolysaccharide or thrombin-binding protease-activated receptor-1 (PAR-1). This evidence concerns the gene F2R and pulmonary edema.