To determine whether S1PR2 mediated sustained pathological inflammation in vivo, we subjected mice to intraperitoneal injection of S1PR2-shRNA (Fig. 3A) S1PR2-shRNA markedly and specifically downregulated S1PR2 expression in the pancreas of acute pancreatitis mice (Fig. 3B). The gene discussed is S1PR2; the disease is acute pancreatitis.