As ALA activated sulfane sulfur/H2S pathway in our study, Takahashi et al. [55] observed that reactive sulfur species such as sulfane sulfur and H2S activate insulin secretory pathway via regulation of tRNA methylthiolation, and inhibited high glucose- and hyperglycemia-induced apoptosis of insulin-secreting pancreatic β-cells [56, 57]. This evidence concerns the gene INS and Hyperglycemia.