SIRT1 and metabolic dysfunction-associated steatohepatitis: In the same studies, the authors reported that activation of the H2S pathway with H2S donor compounds including ALA reduced lipid accumulation in hepatocytes and improved NAFLD and NASH by stimulating hepatic autophagy through activation of AMPK signaling pathway dependent or independent of mammalian target of rapamycin (mTOR; a central regulator of cellular homeostasis) as well as via SIRT1/LKB1/AMPK pathway [69–71].