ESR1 and lung cancer: Despite a higher positive correlation (Pearson correlation coefficient R ≈ 0.84) (Additional file 2: Fig. S1), we determined several known lung cancer-associated genes with high RS and low |log2FC| (Table 2 and Additional file 2: Fig. S1), such as TRIM28, APP, ESR1, MYC, and EGFR [56–59].