Previously, Thorsson et al. proposed four immune subtypes according to the relative abundance of different subpopulations of immune cells: C1 (wound healing), C2 (interferon-gamma [IFN-γ] dominant), C3 (inflammatory), and C4 (lymphocyte depleted), and the immune subtypes C2 had a high proliferation rate and is highly correlated with mutated gastric cancer [33]. This evidence concerns the gene IFNG and gastric cancer.