Moreover, an antibody blocking integrin α6β4, as well as small-molecule inhibitors of integrins αvβ3 and αvβ5, significantly decreased the migration of A375 cells lacking NECTIN1 (Fig. 5h,i), directly implicating these integrins in the motility of adherens junction-incompetent melanoma cells. The gene discussed is NECTIN1; the disease is melanoma.