IGF1R and melanoma: These results were confirmed in vivo by expressing IGF1R* in nectin1-deficient zebrafish melanomas, which accelerated tumor onset compared to a GFP-negative control (Extended Data Fig. 10a), in line with the generally protumorigenic role of aberrant IGF1 signaling, although we did not detect significant differences in tumor cell proliferation by phospho-Histone3 staining of zebrafish melanoma sections (Extended Data Fig. 10b).