PLCB4 and neoplasm: Analysis of tumour biopsies (n = 63) showed that 61 (97%) had likely loss of one copy of BAP1 (Methods), 23 (37%) had mutations in the gene encoding GNAQ, 26 (41%) in GNA11, three (5%) in CYSLTR2, one (2%) in PLCB4 and 11 (17%) in SF3B1.