PLCB4 and uveal melanoma: Nearly all cases of uveal melanoma harbor one of four initiating oncogenic driver mutations in GNAQ, GNA11, PLCB4 or CYSLTR2 in a mutually independent fashion, as well as a secondary oncogenic event affecting EIFA1X, BAP1 or genes encoding for spliceosome components, most commonly SF3B1 (refs. 8–10).