The KEGG pathways that were most significantly enriched by the sEV miRNAs in the module MEbrown were the Hippo signalling pathway, endocrine resistance, pathways in cancer, MAPK signalling pathway, and mTOR signalling pathway (p = 2.25E-05, p = 2.30E-05, p = 2.43E-05, p = 1.30 E-04), as shown in Fig. 6f. Here, MTOR is linked to cancer.