Some of the genes of interest included the neuropeptide, PNOC, the immune related gene, C4B (upregulated and also the 14th most dysregulated AD gene), the transcription factor, BCL11A (downregulated and also the 20th most dysregulated gene), and additional genes previously linked with AD, including ANK3, MS4A6A, AGFG2, CYC1, HLA-DRA, MEG3, MT2A, NCALD, NEU1, PSMC3, SERPINB6, and SPARC (see full list in Supplementary File 1). Here, SPARC is linked to Alzheimer disease.