PNOC and Alzheimer disease: 41 genes from a recent human GWAS AD study25 were among the top 1000 AD dysregulated genes (Fig. 1, Supplementary File 1), including the opioid neuropeptide, PNOC, downregulated and connected to AD46, the immune related gene, C4B, upregulated and linked with AD47, and the transcription factor, BCL11A, downregulated and associated with cortical neuron differentiation48.