STAT3, SOX9, ELK1, and SOX2 affected the most genes, but other transcription factors of interest included PAWR, GLIS3, AFF1, TCF3, FOXO1, BCL6, CEBPD, YAP1, RXRA, NFKB1, and NEUROD6 as these have previously been linked to AD within curated databases of diseases53,55–57. The gene discussed is FOXO1; the disease is Alzheimer disease.