CD274 and neoplasm: Interestingly, treatment of CARMz T cells with AZ did reduce the tumor-lysing capacity of the mixture of CARMz T and CARP T cells (Fig. 2c), suggesting that CARP T cells augmented cytotoxicity of CARMz T cells possibly through physical interactions between PD-L1 on CARMz T cells and CSR on CARP T cells (Fig. 2d).