CD8A and neoplasm: To rule out the possibility that our observation is B16 tumor-specific, we employed a different tumor model, i.e., colorectal cancer line MC38 expressing model antigenic peptide GP33-41 (MC38-GP33-41) together with P14 TCR transgenic mice carrying CD8+ T cells recognizing GP33-41 presented by MHC-I molecule H-2Db (Fig. S7a).