Interestingly, this pattern of gene signature enrichment was TDLN-specific, in TIL Pmel-1 T cells, stem T cell signatures (both TRM stem and non-TRM stem) were enriched in WT while effector and terminally exhausted T cell signatures were enriched in Tgfbr2−/− samples (Fig. 9d), presumably due to the facts that T cell migration from TDLN to tumor was inhibited by FTY720 and enhanced differentiation from stem→effector occurred inside tumor in the absence of TGF-β signaling. Here, TGFB1 is linked to neoplasm.