Indeed, the accumulation of H3K4me2 observed in human and mouse ETP-ALL was decreased by targeting LSD1 (with GSK-LSD1 or SP2509) in combination with JAKi, which led to a global reverse of the H3K4me3:H3K4me2 and H3K4me2:H3K4me1 ratios (Fig. 3C, Fig. 7C). Here, KDM1A is linked to acute lymphoblastic leukemia.