In addition, the IL7 cytokine is an essential factor for leukemic cell growth that might be highly consumed during cultures as also seen in vivo upon leukemia development [17, 18], which lead us to the hypothesis that this extrinsic factor may play an important role in the resistance process of Zeb2Tg ETP-ALL to LSD1i. The gene discussed is IL7; the disease is acute lymphoblastic leukemia.