Interestingly, we noticed strong expression of the anti-apoptotic BCL2 gene in the presence of IL7 in Zeb2Tg ETP-ALL cells; in contrast, treatment with LSD1i activated the transcription of several genes encoding for pro-apoptotic proteins (e.g. Bcl2l11/BIM) (Fig. 2D, E), findings that were confirmed at the protein level (Fig. 2F). Here, BCL2 is linked to acute lymphoblastic leukemia.