Through this present study, we have demonstrated the specific role played by ZEB2 and NuRD complex (through its enzymatic demethylase subunit LSD1/KDM1A) in the regulation of the intrinsic apoptosis pathway, which reiterates the therapeutic potential of targeting epigenetic co-factor LSD1 to cure ETP-ALL. This evidence concerns the gene MBD2 and acute lymphoblastic leukemia.