BCL2L11 and acute lymphoblastic leukemia: The promoter of Bcl2l11 (BIM) gene also showed an enrichment of the repressive mark H3K27me3 in mature T-ALL whereas in the Zeb2Tg ETP-ALL, we noticed more an enrichment of H3K4me2 mark and reduction in the active H3K4me3 mark (Fig. S5C, D), which is known to be the H3K4 methylation pattern in TSS (promoter) regions of “poised” genes [13, 25].