Surprisingly, although a transgenic mouse ETP-ALL cell line that overexpresses Zeb2 (Zeb2Tg), as well as human derived ETP-ALL cell lines (e.g. LOUCY) that have increased ZEB2 expression, are relatively sensitive in vitro to a catalytic LSD1 inhibitor, human ETP-ALL LOUCY cells were unresponsive to this drug in vivo [11]. The gene discussed is ZEB2; the disease is acute lymphoblastic leukemia.