BCL2 and acute lymphoblastic leukemia: Intriguingly, in mouse and human ETP-ALL, the treatment with LSD1i led not only to increase expression of BIM, but also to slight increases the BCL2 expression that is already highly expressed, which keeps the ratio BCL2/BIM (anti- /pro-apoptotic) similar in untreated cells (Fig. 2E, F and Fig. 3A).