No relevant sequence features existed in differentially spliced exons and 5’SS and 3’SS (Supplementary Fig. S1F, G), although we found that the DDX41 deficiency induced splicing changes in genes partially similar to those seen in myeloid malignancies with mutations in RNA splicing factors accompanied by impaired mRNA production (Supplementary Fig. S1H, I, J, K). This evidence concerns the gene DDX41 and myeloid neoplasm.