In the digestive tract, the 2017 World Health Organization (WHO) classification scheme places neuroendocrine tumors into four main categories, including NET grade 1 (G1), NET G2, NET G3, and NEC (neuroendocrine carcinoma) G3, according to the mitotic activity and Ki-67 labeling index1. This evidence concerns the gene MKI67 and neuroendocrine neoplasm.