CXCL2 and COVID-19: Using this information, as illustrated for the RBPJ and CXCL2 genes (Fig. 4b and Supplementary Fig. 7a), we revealed that, in total, approximately 33% of CHIP (+) upregulated genes in classical monocytes of severe COVID-19 patients were associated with hypo-DMRs either in proximal (within 15 kb) or long-range chromatin interactions (over 15 kb but less than 2 Mb) denoted as ‘hypo-DMR linked genes’ (Supplementary Fig. 7b).