We integrated a total of 79,011 high-quality single-cell transcriptome profiles of peripheral blood mononuclear cells (PBMCs) generated by the 10x Genomics single-cell RNA-seq (scRNA-seq) platform, comprising healthy control (n = 4), CHIP (+) uninfected control (n = 2), severe influenza (n = 5), CHIP (-) mild COVID-19 (n = 5), CHIP (-) severe COVID-19 (n = 3), CHIP (+) mild COVID-19 (n = 4), and CHIP (+) severe COVID-19 (n = 6) specimens (Supplementary Tables 1, 3, 4, see Methods). This evidence concerns the gene STUB1 and influenza.