While the protective nature of SGs in the work by Lee et al.38 and Lee and Han51 was also dependent on IFNγ, since all mice depleted of IFNγ prior to SGs administration fully succumbed to infection similar to what we observed here, both immunocompetent and CD4-deficient mice exhibited only ~60–70% survival in these studies while we show complete (100%) survival in both of these conditions. This evidence concerns the gene IFNG and infection.