CD4 and hyperinsulinemic hypoglycemia, familial, 4: This same trend was also apparent for the IFNγ- and IL-17A-producing CD4+ T cell response during CD8-deficiency compared to the IFNγ- and IL-17A-producing CD8+ T cell response during CD4-deficiency (Fig. 1e–h), although this difference may possibly be attributed to experimental variation between different groups of mice.