The seven prevalent ‘candidate genes’ (ADAM10, ADAM17, AKT1, CTNNB1, ESR1, FGFR1, PIK3CA) showed direct associations with enriched terms under the categories of ‘Neurodegenerative disorders’, ‘Neurodevelopmental diseases’, ‘CNS tumour/cancer’ and ‘Cellular Signaling pathways’. This evidence concerns the gene AKT1 and central nervous system neoplasm.