In addition, the Hippo pathway was inhibited and the expression of YAP/TAZ and their downstream targets was increased in another obese mouse model, which was HFD-induced obesity, accompanied by a robust induction of fibrotic program (Fig. 1e–h and Supplementary Fig. 1k–m). The gene discussed is YAP1; the disease is obesity due to melanocortin 4 receptor deficiency.