Lats1 and Lats2 play a redundant role in maintaining AT homeostasis as revealed by that single knock-out of Lats1 (L1-AKO) or Lats2 (L2-AKO) does not lead to fat loss or induce AT fibrosis (Supplementary Fig. 3o–q), which is consistent with what was reported in other tissues24,25. This evidence concerns the gene LATS2 and ataxia telangiectasia.