SMAD2 and ataxia telangiectasia: Notably, overexpression of TGFβRI (T204D) in L1L2-FF mice did not influence adipocyte identity and fibrosis albeit elevating SMAD2 phosphorylation and nuclear localization of p-SMAD2 in scWAT (Fig. 2d and Supplementary Fig. 7c, h–k), indicating that activation of TGFβ signaling alone is not sufficient to induce AT fibrosis.