Expression analyses revealed that NOTCH receptors were distinctly enriched in PECAM1+ endothelial cells (clusters 0 and 22) and in BCAM+ vascular SMC (cluster 13) (Fig. 4a–d, Supplementary Fig. 6a, b) in both the ICC/IDC TME and the benign prostate microenvironment. Here, PECAM1 is linked to intrahepatic cholangiocarcinoma.