Interestingly, club/basal/hillock cells in ICC/IDC-enriched regions had increased inflammatory hallmarks, including TNFα signaling via NFκB, IFNγ response, and IL6/JAK/STAT3 signaling compared to these cell types in benign-enriched prostate (Fig. 3l). Here, STAT3 is linked to intrahepatic cholangiocarcinoma.