CTHRC1 and Familial prostate cancer: CTHRC1+, ASPN+, and FAP+ CAF were located peri-epithelial to ICC/IDC and were significantly enriched in ICC/IDC compared to benign prostate as well as Gleason pattern 3 and Gleason pattern 4 non-ICC prostate cancer (Fig. 5m, n and Supplementary Fig. 7c, d).