While monocyte markers (VCAN and S100A9) mapped to cluster 18, cluster 4 cells expressed dendritic cell markers (CD1C and CLEC10A) as well as macrophage markers associated with disease recurrence in clear cell renal cell carcinoma (C1QB, TREM2, and APOE)80 (Fig. 7b). This evidence concerns the gene APOE and clear cell renal carcinoma.