A gene signature based on these cells (C1QB, TREM2, APOE, CD163, MRC1, and MSR1) showed a significant association with worse prostate cancer progression-free survival in the TCGA PanCancer Atlas prostate adenocarcinoma cohort74 and worse disease-free survival in the MSKCC Prostate Adenocarcinoma cohort75 (Fig. 7j). Here, TREM2 is linked to prostate adenocarcinoma.