To better delineate myeloid heterogeneity in the ICC/IDC TME, clusters 4 and 18 were re-clustered to 7 clusters (Mac0-6) with Mac1 and Mac4 almost entirely derived from cluster 18 while Mac0, Mac2, Mac3, Mac5, and Mac6 were largely derived from cluster 4 (Fig. 7f, genes for Mac0-Mac6 in Source Data). The gene discussed is LGALS3; the disease is intrahepatic cholangiocarcinoma.