BAX and acute megakaryoblastic leukemia: In AMKL tumorigenesis model, cells harvested from Dami-DEL established ascites were larger with poly-lobulated nuclei and less apoptotic as evidenced by increased Bcl-2, decreased Bax and DDIT3 compared to control Dami-GFP/Dami-PM (Fig. 5B, C and Fig. S5A).