In our previous work, we had observed that the c-Mpl-del appears in human AMKL Dami cells, a subtype of AML, by targeting c-Mpl sequence, which could bind TPO and activate ERK1/2 signaling in c-Mpl-del-transfected NIH3T3 cells [27]. The gene discussed is MPL; the disease is acute myeloid leukemia.