Diabetes also reduced phospho-Akt1, but not total Akt1, in both WT diabetic and Akt2 KI diabetic mice compared to corresponding nondiabetic controls, suggesting that Akt2 KI had no effect on the diabetes-induced downregulation of phospho-Akt1 in the RPE (Supplementary Fig. 5d, e). The gene discussed is AKT1; the disease is diabetes mellitus.