For tau PET, we also observed significant interaction effects of diagnosis × time, with steeper increases in BPND in MCI/AD than in SCD in temporal (β = 0.08, P = 0.049) and neocortical (β = 0.12, P < 0.02), but not entorhinal (β = 0.08, P = 0.14), regions (Fig. 4). Here, MAPT is linked to Alzheimer disease.