MFN2 and Charcot-Marie-Tooth disease type 2A1: The importance of these processes in organismal health is highlighted by the fact that mutations in MFN2 or OPA1 lead to Charcot-Marie-Tooth syndrome Type 2A (CMT2A) and dominant optic atrophy (DOA), respectively (Alexander et al, 2000; Delettre et al, 2000; Züchner et al, 2004; Stuppia et al, 2015).