After comparing mutation rates in 10 established cancer pathways (Sanchez-Vega et al, 2018, Fig S5), we found TP53 (P = 0.037), apparently because of the differential mutational profile of TP53 alone, and Hippo (P = 0.042; Table S9 and Fig S5) to be differentially mutated. The gene discussed is TP53; the disease is cancer.