KIF26A and cerebral malformation: As part of a rare variant, family-based genomics approach by exome sequencing (ES) to identify genes associated with brain malformations, we found 5 unrelated subjects with congenital brain malformations who had inherited biallelic mutations in KIF26A (NM_015656.1, hg19) (Figure 1A and B) but no other rare, segregating, or likely damaging candidate variant alleles (Table S1).