HPS5 and infection: These results showed that in the infection of HPS5-SQ, STEC Claudin-1 in the cytoplasm first decreased, and intercellular Claudin-1 was partially damaged, indicating that cytoplasmic Claudin-1 was enveloped and degraded by autophagic degradation and autophagy degrading cytoplasmic Claudin-1 may affect the supply of Claudin-1 to the cell membrane.