The above results showed that HPS5-SQ induced STEC complete autophagy and HPS5-SQ infection destroyed the integrity of Claudin-1 with concomitant autolysosome maturation in STEC, which was consistent with an increased number of autolysosomes in the infection of HPS5-SQ in 12 h (Fig 3D–3F). The gene discussed is CLDN1; the disease is infection.