Thus, while the emergence of a LRRC15+ pathological fibroblast population may ultimately drive the fibrotic changes observed in patients with COVID-19, these fibroblasts may initially play a protective role by contributing to viral clearance during the acute phase of infection through their expression of LRRC15 on the cell surface, subsequently paving the way for the transition toward tissue repair and remodeling. This evidence concerns the gene LRRC15 and COVID-19.