We first performed the univariate cox regression and found that the elevated expressions of HDAC7, HDAC3, and HDAC1 were associated with poor prognosis while increased expressions of HDAC6, HDAC5, HDAC4, and HDAC11 were favorable for prognosis in low-grade glioma (Fig 2A). This evidence concerns the gene HDAC4 and central nervous system cancer.