STOX1 and hypertensive disorder: Transgenic mice overexpressing the human storkhead box 1 (STOX1) gene in the placenta exhibit many preeclamptic features, including increased blood pressure (35, 56), but a limitation of this model is that hypertension develops at day 3 of pregnancy, which is much earlier than reported in preeclamptic women and prior to establishment of the mature mouse placenta around E10.5 (35).