ITGAX and myocarditis: As CD11c-DTR mice are sensitive to Dtx due to adverse effects causing fatal fulminant myocarditis (30), we reconstituted lethally irradiated WT mice with BM cells from CD11c-DTR mice (donor) to generate mice that present DTR only in CD11c+ cells of the hematopoietic compartment (CD11cDTR/hema mice) (Figure 4B).