ACLY and cancer: The expression levels of GLUT4, SREBP, ChREBP, ACL, and ACC2 were significantly increased in MKN28 control cells but not in GLUT4-KD cells under serum starvation compared with normal conditions (Supplemental Figure 6B), indicating that GLUT-mediated glucose uptake was required for viperin-mediated cancer metabolic reprogramming.