CD4 and COVID-19: Current US Centers for Disease Control and Prevention (CDC) guidelines recommend risk reduction behaviors (ie, mask wearing), an additional COVID-19 primary series vaccine dose, and a second booster dose for PWH with “advanced or untreated HIV infection.”21,22 PWH with partially recovered CD4 cell counts (>200 cells/μL) and moderate immune suppression are not currently recommended for an additional or second booster dose.