In this study, we identified 10,415 women with early-stage breast cancer and divided them into three special subgroups (breast-conserving surgery + T1N0M0 + ER-positive, mastectomy + T3N0M0, and mastectomy + T1-2N1M0, respectively) based on the guideline classification and the indications for surgery. This evidence concerns the gene ESR1 and breast carcinoma.