CBD, on the other hand, is suggested to decrease THC-induced anxiety either by acting as a negative allosteric modulator of CB1 receptors (Hayakawa et al. 2008; Laprairie et al. 2015), or via inhibiting fatty acid amide hydrolase, thereby increasing anandamide concentrations which then compete with THC for CB1 receptor binding (Pertwee 2008), or by activating transient receptor potential vanilloid 1 which oppose the effects of CB1 receptors (Iannotti et al. 2014; Lisboa and Guimaraes 2012), or via modulation of 5-HT1a receptors (Zuardi et al. 2017a). The gene discussed is HTR1A; the disease is Anxiety.