KEGG pathway assessments indicated that these genes were involved in EGFR tyrosine kinase inhibitor resistance, endometrial cancer, longevity regulation, prolactin signaling, HIF-1 signaling, Neurotrophin signaling, Thyroid hormone signaling, FoxO signaling, cellular senescence, and the JAK/STAT pathway (Table 3). The gene discussed is BDNF; the disease is endometrial cancer.