Our previous biochemical studies showed that ZIKV infection induces Mib1-mediated degradation of PCM1 that participates in stabilization of centrosomes and microtubule organization (26), and here, we found that ZIKV induced ubiquitination-mediated degradation of Cx43 that is vital for heart syncytia function, modulates rhythmic locomotor activity, and mediates syncytia conduction of the heart (64). This evidence concerns the gene MIB1 and Zika virus infectious disease.