GJA1 and infection: We found that ZIKV replicated in multiple organs of 3- to 4-week-old A129 mice after infection, induced significantly higher levels of creatine-kinase (CK), CK-MB, lactate dehydrogenase (LDH), alpha-hydroxybutyrate dehydrogenase (α-HBDH), cardiac troponin T (cTnT), and cardiac troponin I (cTnI) and abnormal electrocardiogram (ECG) presentations that are the biomarkers for acute myocardial injury, decreased the gap junction protein Cx43, and altered the structure of the intercalated disc (ICD).