Our previous biochemical studies showed that ZIKV infection induces Mib1-mediated degradation of PCM1 that participates in stabilization of centrosomes and microtubule organization (26), and here, we found that ZIKV induced ubiquitination-mediated degradation of Cx43 that is vital for heart syncytia function, modulates rhythmic locomotor activity, and mediates syncytia conduction of the heart (64). The gene discussed is GJA1; the disease is Zika virus infectious disease.