The importance of T cells in acute infection is characterized in the correlation between activation markers via memory CD4+ T cells (helper) present in the peripheral circulation with higher levels of CD4+ T cells at 2 years post-infection.13 CD4+ T lymphocytes are the primary cellular targets of HIV; however, the activation state of CD4+ T lymphocytes appears to have a significant impact on the virus' ability to infect these cells.14 With regard to the contribution of B T-bet+ cells, it has shown that these are linked with the memory response to the HIV-binding protein.15 The gene discussed is CD4; the disease is infection.