The role of these drugs in psoriasis was reviewed and suggested that they inhibit the proliferation of epidermal cells via inhibiting the autophosphorylation of epidermal growth factor receptor, signaling of extracellular signal-regulated kinases/mitogen-activated protein kinase (ERK/MAPK) and inhibition of transforming growth factor (TGF)-β in keratinocytes. This evidence concerns the gene EGFR and psoriasis.