HLA-DRB5 and Alzheimer disease: They found single nucleotide polymorphisms (false discovery rate p < 0.05) were associated with both AD and immune-mediated diseases, of which rs2516049 (closest gene HLA-DRB5; conjunction false discovery rate p = 0.04 for AD and psoriasis, 5.37 × 10−5 for AD, and 6.03 × 10−15 for psoriasis) demonstrated the same direction of allelic effect between AD and psoriasis (Yokoyama et al., 2016).