As for the role of PPAR in NDs, it appears that ligands of PPAR β/δ and PPAR γ have antioxidant properties and protect neuronal cells from apoptosis, as well as reduce the inflammatory activation of astrocytes and microglia and their production of pro-inflammatory cytokines and NO, which exert neurotoxic influence, but the nature of PPAR β/δ is opposite in NDs and psoriasis (Menendez-Gutierrez et al., 2012). The gene discussed is PPARA; the disease is psoriasis.