The role of celastrol, a Chinese medical plant derivative, was described by Venkatesha et al. It is involved in the following cell signaling pathways, which are documented to be relevant in psoriasis pathogenesis and are mediators of neurodegenerative processes at the same time: NF-κB pathway, MAPK, JAK/STAT, and PI3K/Akt/mTOR (Kempuraj et al., 2016; Lin and Huang, 2016; Venkatesha and Moudgil, 2016). The gene discussed is MTOR; the disease is psoriasis.