Amongst an array of signaling pathways aberrantly activated in cancer Wnt, JAK/STAT, PI3k/Akt/mTOR, Notch, NF‐κB, Hedgehog, and TGF‐β/Smad pathways are crucial for the of self‐renewal, cell growth, metastasis of CSCs, and angiogenesis. This evidence concerns the gene AKT1 and cancer.