PPFIA4 and metastatic colorectal cancer: In previous studies, PPFIA4 was confirmed to enhance colorectal cancer glycolysis, which in turn promotes cell proliferation and migration [17] Li et al. [39] performed a comprehensive integration of metastatic colorectal cancer (mCRC) genomics, proteomics, and phosphoproteomics and referred that the PPFIA4 gene has a higher mutation frequency in CCRC.